The San Francisco 49ers have a quick turnaround after they fell to the Jacksonville Jaguars on Sunday at Levi’s Stadium, as they’ll take on the Los Angeles Rams for an NFC West battle at SoFi Stadium on Thursday night.

While this matchup will have plenty of drama, San Francisco will be without a number of key players on Thursday, as indicated on their Wednesday injury report.

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This report listed quarterback Brock Purdy (toe), wide receiver Ricky Pearsall (knee), wide receiver Jauan Jennings (ankle/rib), wide receiver Jordan Watkins (calf) and defensive end Robert Beal Jr. (ankle) as out this week.

Defensive lineman C.J. West, who missed last week with a thumb injury, is questionable for Thursday.

Quarterback Mac Jones (knee) was a full participant all week, so he’ll get the start against Los Angeles. San Francisco will have to bring up Adrian Martinez from the practice squad to serve as a backup.

Without Pearall, Jennings and Watkins at wide receiver, the 49ers are left with Demarcus Robinson, Kendrick Bourne, Marquez Valdes-Scantling and Skyy Moore on the roster at the position. They’ll likely have to call up one of Russell Gage, Junior Bergen and Malik Turner from the practice squad.

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This article originally appeared on Niners Wire: 49ers suffer crushing blow on injury report for huge Week 5 game