Red Sox vs. White Sox odds, line, prediction, time: 2025 MLB picks, bets for Patriots' Day from proven model

The Boston Red Sox continue their tradition of playing a home game on Patriots’ Day morning on Monday when they host the Chicago White Sox at Fenway Park. The Red Sox have been scheduled to play a home game on Patriots’ Day every year since 1959 and have started the contest at 11:10 a.m. every year since 1968 to allow people to also witness the Boston Marathon later that day. Monday will wrap up a four-game series between the two teams with the Red Sox (12-11) taking the first two games and the White Sox (5-16) winning, 8-4 on Sunday. The Red Sox are 71-56 (.559) all-time on Patriots’ Day.

First pitch from Fenway Park in Boston, Mass., is set for 11:10 a.m. ET. Boston is a -290 favorite on the money line (risk $298 to win $100) in the latest White Sox vs. Red Sox odds, while Chicago is a +235 underdog on DraftKings Sportsbook. The over/under is 9 in the latest MLB odds. Before making any Red Sox vs. White Sox picks for Patriots’ Day, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 4 of the 2025 MLB season on an 8-3 run on MLB money-line betting picks (+340). Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Red Sox vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several MLB odds and betting lines for White Sox vs. Red Sox:

Red Sox vs. White Sox money line: Boston -290, Chicago +235 at DraftKings Sportsbook
Red Sox vs. White Sox over/under: 9 runs
Red Sox vs. White Sox run line: Boston -1.5 (-130)
CHI: The White Sox are 5-4 as an away underdog on the run line this season
BOS: The Over is 4-2 over the last six Red Sox games
Red Sox vs. White Sox picks: See picks at SportsLine
Red Sox vs. White Sox streaming: FuboTV (Try for free)

Why the White Sox can cover

Chicago is off to another slow start at 5-16, but the White Sox are coming off an 8-4 win on Sunday, which is tied for their second-best run-producing game of the season. First baseman Andrew Vaughn went 2-for-5 with a two-run home run and catcher Matt Thaiss added a three-run home run to fuel the victory. Monday will already be the seventh time the White Sox meet the Boston and they are 3-3 against the Red Sox compared to 2-13 against the rest of baseball.

Jonathan Cannon gets the start for the White Sox, coming off throwing 4 1/3 shutout innings against Oakland on Wednesday. He hasn’t allowed a run in two of his first four starts this year and the 24-year-old right-handed pitcher has a 4.42 ERA this season. Cannon had a 4.49 ERA in 23 games (21 starts) as a rookie last season, including a 3.77 ERA over his final five starts as he became more comfortable against major-league lineups. See which team to back at SportsLine.

Why the Red Sox can cover

Boston scored 18 runs over the first three games against the White Sox this series, which started with a 10-3 victory on Friday. Shortstop Trevor Story went 3-for-4 with two home runs and six RBI on Friday. Third baseman Rafael Devers has rebounded from his slow start by reaching base multiple times in four straight games and he had a home run against Chicago on Saturday. The White Sox are 27th in baseball at 3.24 runs per game, meanwhile, Boston ranks 11th at 4.52 runs per contest.

The Red Sox are starting Walker Buehler, who signed a one-year, $21.05 million contract with Boston this offseason. The 30-year-old RHP struggled last season with the Dodgers, but he entered last year with an ERA below 3.50 in four of his first five full MLB seasons. The two-time All-Star was fourth in the National League Cy Young voting in 2021 as he had a 2.47 ERA over 33 starts. He has a 2.38 ERA over his last two starts entering a contest that always means more to the people of Boston, which has translated to a winning record on Patriots’ Day. See which team to back at SportsLine.

How to make Red Sox vs. White Sox Patriots’ Day picks

SportsLine’s model is leaning Over on the total, and it says one side of the money line is the better value. You can head to SportsLine to see the model’s MLB picks.

So who wins Red Sox vs. White Sox, and which side is the better value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.