Monday Night Football brings us the resilient San Francisco 49ers — a team that has overcome myriad injuries thus far — hosting the feisty Carolina Panthers.

This contest should see both teams attempting to establish the run early on. However, only the Bay Area-based franchise should be trusted in that regard, so rely on these two aerial props and the safest two-score bet you’ll find.

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There’s a natural crossover between fantasy football and NFL player prop bets. If you haven’t participated in sports betting but love fantasy sports, this is as fine as any place to begin. You can wager as little as pennies just to get your feet wet. Aside from the thrill of winning real money, it’s a fun way to test your knowledge and prognostication skills.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Panthers WR Tetairoa McMillan 70+ Receiving Yards (-103)

The standout rookie has hit this number in four games this season, missing out by fewer than eight yards twice. McMillan has at least 60 yards in the two most recent appearances, putting momentum on his side. The Niners have been gouged for 70 or more a half-dozen times in 2025, but the position has logged at least 62 yards in seven others. There’s a strong chance San Fran puts the Panthers into a negative game script, which thoroughly favors McMillan.

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49ers TE George Kittle 60+ Receiving Yards (+101)

The earlier talk about establishing the run leads us to this bet … Reaching this modest line in consecutive games, Kittle presents a fine double-up opp for bettors who aren’t so concerned about defensive matchup metrics and prefer to ride the hot hand. He should kill Carolina on play-action passing. TEs have registered only three 60-plus-yard efforts and a 59-yarder. Hardly any of the opponents faced were of Kittle’s caliber, and the San Francisco standout offers a worthwhile risk-reward prop.

49ers RB Christian McCaffrey 2+ Anytime TDs (+135)

It’s not too often you see a pair of anytime TDs with odds less than +200, but that’s a testament to how good CMC is as well as the Panthers’ suspect RB defense. The position has scored 11 times in as many games, including every 25.67 handles on the ground. Another favorable McCaffrey wager to consider: six-plus receptions (+103).

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Same-Game Parlay for Panthers at 49ers

If you’re feeling confident in all three of these legs hitting, the SGP is worth tossing a few bucks at. The current odds are +330 for the aforementioned combined bets. Only two, however, are able to be parlayed.

This story was originally reported by Athlon Sports on Nov 24, 2025, where it first appeared in the Sports Betting section. Add Athlon Sports as a Preferred Source by clicking here.