New England also placed LB Curtis Jacobs on injured reserve and waived OLB Ochaun Mathis.
Leo, 25, was drafted by the Colts in the sixth round of the 2023 NFL Draft out of Wagner.
He signed a four-year, $4 million rookie contract and was in the second year of that deal when the Colts waived him coming out of the preseason. He was re-signed to the practice squad.
He has yet to appear in an NFL game.
ROSTER MOVES:
According to the team, the Patriots have made the following transactions:
— EDGE Titus Leo signed off of the Colts practice squad to the 53 man roster
— LB Curtis Jacobs placed on injured reserve
— EDGE Ochaun Mathis has been released