Will Brandon Aiyuk play in 2025? Latest injury update on 49ers wide receiver

Will Brandon Aiyuk play in 2025? Latest injury update on 49ers wide receiver originally appeared on The Sporting News

As the San Francisco 49ers navigate their Week 5 matchup against the Los Angeles Rams, the absence of wide receiver Brandon Aiyuk is as glaring as ever.

Advertisement

The 49ers have been dealing with injuries to their other wide receivers over the first four weeks. Jauan Jennings is set to miss his second game of the season on Thursday night, and Ricky Pearsall is missing his first.

Of course, Aiyuk has been on the physically unable to perform list since the offseason as he works his way back from tearing his ACL and MCL last October. It will have been a full year since Aiyuk suffered the injury on Oct. 20, 2024.

So, when can we expect Aiyuk to return? Here’s everything we know.

Will Brandon Aiyuk play in 2025?

There has been no indication Aiyuk will miss the entire 2025 season, but it doesn’t look like he’s going to return soon, either, even though he is now eligible to be activated from the PUP list.

Advertisement

General manager John Lynch addressed Aiyuk’s status on Sept. 25 and revealed that the star wideout has not suffered any setbacks, but he’s also “not close” to coming back yet.

“No setbacks,” Lynch said of Aiyuk. “There’s different levels when you do these ACLs, and Brandon had a fairly significant injury, involving a lot of different things in his knee. He’s a really gifted athlete. He’s a very hard worker. And so when you combine that, you tend to come back at a good clip.

“There’s no absolutes on these things. So he’s got to continue to hit markers, but he is tracking well,” Lynch added. “He’s working hard. And we’ll just continue to do that. We’ll be a better team when Brandon is out there. And so we look forward to that day, but you know, it’s not close. When we have some more information on that, we’ll be forthright with it.”

While that was a grim update, head coach Kyle Shanahan attempted to clarify what Lynch said to make it sound more positive.

Advertisement

“No, I think it’s more like when we get kind of an exact target date,” Shanahan said. “That’s when you look at it that way. I think we’re getting close to that. But just not to have a target date is that’s when I start thinking about it and we don’t have that yet. So, we’re waiting until they give us one.”

The first step for Aiyuk to come back is being designated to return from the PUP list. From there, the Niners will have 21 days to active him to the 53-man roster.

At this point, it’s anyone’s guess what week exactly Aiyuk will be back, but again, we are still assuming he will be back at some point in 2025 until told otherwise.

More NFL News

Related Posts

🚨 Time Update: Eagles vs. 49ers at Lincoln Financial Field — Kickoff Time Confirmed for NFL Playoffs Wild Card Round

🚨 Time Update: Eagles vs. 49ers at Lincoln Financial Field — Kickoff Time Confirmed for NFL Playoffs Wild Card Round The NFL Playoffs are officially here, and…

BREAKING: Phіlаdelрhіа Eаgleѕ heаd coаch Nіck Sіrіаnnі hаѕ fіled а lаwѕuіt аgаіnѕt NFL FOX commentаtor Troy Aіkmаn іn NFL court, аccuѕіng hіm of mаkіng “іnѕultіng аnd dіѕreѕрectful” ѕtаtementѕ durіng а рreѕѕ conference followіng а humіlіаtіng 17-24 loѕѕ to the wаѕhіngton commаnderѕ . Nіck Sіrіаnnі clаіmѕ thаt Troy Aіkmаn’ѕ commentѕ cаuѕed ѕіgnіfіcаnt dаmаge to the Eаgleѕ’ honor….

аccordіng to thіѕ fіctіonаl court fіlіng, ѕіrіаnnі clаіmѕ аіkmаn’ѕ remаrkѕ croѕѕed the lіne from аnаlyѕіѕ іnto рublіc humіlіаtіon, іnflіctіng “іrreverѕіble hаrm” on the eаgleѕ’ honor, culture, аnd leаderѕhір credіbіlіty….

🚨 BREAKING: Travis Kelce’s Disappointing Exit—Andy Reid Slams for His Handling of the Last Game! Was this a missed opportunity for the Chiefs’ star? Fans are furious! 👇👇👇

Andy Reid was called out by Kansas City Chiefs fans for not prioritizing tight end Travis Kelce on offense, with supporters fearing Sunday’s game could be his…

💥 GAME-CHANGING MOVE: Dаllаѕ Cowboyѕ Announce Hiring Homeless People to Clean AT&T Stadium After Every Weekend Game—$20 an Hour Plus Hot Food and Drinks! This Unexpected Opportunity Is Changing Lives and Redefining What It Means to Give Back. 👇👇👇

When the fіnаl whіѕtle echoeѕ through аT&amр;аmр;аmр;аmр;аmр;аmр;T ѕtаdіum аnd more thаn 80,000 fаnѕ рour out іnto the Texаѕ nіght, moѕt рeoрle аѕѕume the ѕtory of gаme dаy…

RESPECT: Aaron Rodgers Silences Acrisure Stadium With a Quiet Gesture Before the New Year’s Game

Just minutes before kickoff at Acrisure Stadium, as Terrible Towels waved and the cold air sharpened the noise, Aaron Rodgers delivered a message without words. There was…

BREAKING NEWS: San Francisco 49ers legend Jerry Rice suddenly admitted a hard truth after the 49ers’ 3–13 loss to the Seattle Seahawks — “The loss wasn’t just about bad calls. Poor execution, missed opportunities, and crucial moments going against us all played a role in how this game slipped away.” He went on to point out a series of controversial decisions that appeared to swing momentum toward the Seahawks, combined with San Francisco’s own late-game mistakes, ultimately sending shockwaves across the entire NFL 👇

BREAKING NEWS: San Francisco 49ers legend Jerry Rice suddenly admitted a hard truth after the 49ers’ 3–13 loss to the Seattle Seahawks — “The loss wasn’t just…