{"id":139789,"date":"2026-01-14T23:14:17","date_gmt":"2026-01-14T23:14:17","guid":{"rendered":"https:\/\/sportnews.azontree.com\/?p=139789"},"modified":"2026-01-14T23:14:17","modified_gmt":"2026-01-14T23:14:17","slug":"%f0%9f%94%a5-game-changer-49ers-vs-seahawks-nfc-divisional-round-seattle-favored-but-can-san-francisco-defy-the-odds-in-a-must-win-game-at-lumen-field-latest-predictions-odds-a","status":"publish","type":"post","link":"https:\/\/sportnews.azontree.com\/?p=139789","title":{"rendered":"\ud83d\udd25 GAME CHANGER: 49ers vs. Seahawks NFC Divisional Round \u2014 Seattle favored, but can San Francisco defy the odds in a must\u2011win game at Lumen Field? Latest predictions, odds, and picks revealed! \ud83d\udc47"},"content":{"rendered":"<p data-start=\"0\" data-end=\"74\"><strong data-start=\"0\" data-end=\"74\">NFL Divisional Round Preview: San Francisco 49ers vs. Seattle Seahawks<\/strong><\/p>\n<p data-start=\"0\" data-end=\"74\"><img decoding=\"async\" src=\"https:\/\/wp.clutchpoints.com\/wp-content\/uploads\/2026\/01\/49ers-vs-Seahawks-prediction-odds-pick-for-NFC-Divisional-Round.jpg?resize=1200,900\" alt=\"49ers vs. Seahawks prediction, odds, pick for NFC Divisional Round\" \/><\/p>\n<p data-start=\"76\" data-end=\"554\">The highly anticipated NFL Divisional Round is finally here, and it brings with it an exciting matchup between two bitter NFC rivals: the San Francisco 49ers and the Seattle Seahawks. After a season filled with intense matchups, the two teams find themselves tied at 1-1 in their head-to-head meetings, adding extra spice to this playoff encounter. As the stakes get higher, both teams will bring their A-game, knowing that a victory means a step closer to the NFC Championship.<\/p>\n<p data-start=\"556\" data-end=\"593\"><strong data-start=\"556\" data-end=\"593\">San Francisco 49ers&#8217; Playoff Push<\/strong><\/p>\n<p data-start=\"595\" data-end=\"934\">The San Francisco 49ers enter the NFC Playoffs as the sixth seed, having overcome the Philadelphia Eagles 23-19 on the road in a thrilling Wild Card Round victory. Despite the pressure, San Francisco showed resilience and determination in a tightly contested game, emerging victorious in a matchup that had fans on the edge of their seats.<\/p>\n<p data-start=\"936\" data-end=\"1312\">However, this was not the first time these two teams faced off in the postseason. In Week 18, the 49ers fell short in their regular season finale against the Seahawks, a loss that left them licking their wounds and entering the playoffs as underdogs. Despite this setback, San Francisco is fully aware that they still have the talent and potential to make a deep playoff run.<\/p>\n<p data-start=\"1314\" data-end=\"1695\">With one of the league\u2019s most well-rounded rosters, the 49ers have both offensive firepower and a strong defense to back them up. Their game plan will likely rely on their running game, along with a stout defense to limit Seattle\u2019s offensive output. If San Francisco can establish their running game early and control the tempo of the game, they\u2019ll have a good chance of advancing.<\/p>\n<p data-start=\"1697\" data-end=\"1743\"><strong data-start=\"1697\" data-end=\"1743\">Seattle Seahawks: The Home Field Advantage<\/strong><\/p>\n<p data-start=\"1745\" data-end=\"2249\">The Seattle Seahawks, on the other hand, enter this matchup as the NFC\u2019s number one overall seed, having dominated the league in the latter half of the season. After finishing their regular season with an impressive seven-game win streak, the Seahawks will host the 49ers in what promises to be a raucous atmosphere at their home stadium. Seattle\u2019s home crowd is one of the most passionate and intimidating in the NFL, providing a significant advantage as they attempt to advance to the NFC Championship.<\/p>\n<p data-start=\"1745\" data-end=\"2249\"><img decoding=\"async\" src=\"https:\/\/vsin.com\/wp-content\/uploads\/2026\/01\/USATSI_27985531_168384654_lowres.jpg?w=1068&amp;h=0&amp;crop=1\" alt=\"49ers vs. Seahawks Predictions: NFL Playoffs NFC Divisional Round odds,  picks, and player props - VSiN\" \/><\/p>\n<p data-start=\"2251\" data-end=\"2780\">The Seahawks&#8217; offense has been firing on all cylinders, especially in their Week 18 win against San Francisco. Quarterback Russell Wilson has been sharp, and the team\u2019s running back duo has been effective in moving the ball downfield. Seattle will look to continue their high-powered offensive play while also relying on their defense to make crucial stops when needed. Given their recent form and the boost of playing in front of their home crowd, the Seahawks will certainly feel confident heading into this divisional matchup.<\/p>\n<p data-start=\"2782\" data-end=\"2813\"><strong data-start=\"2782\" data-end=\"2813\">Betting Prediction and Pick<\/strong><\/p>\n<p data-start=\"2815\" data-end=\"3197\">This game promises to be a hard-fought battle, as both teams are evenly matched and carry plenty of momentum into the postseason. For the 49ers, they will need to recover from their Week 18 loss and play with urgency, ensuring that they avoid making mistakes on the road. For the Seahawks, they\u2019ll aim to continue their impressive run and prove they are the team to beat in the NFC.<\/p>\n<p data-start=\"3199\" data-end=\"3518\">Ultimately, Seattle\u2019s home-field advantage and recent momentum should give them the edge in this highly anticipated matchup. However, the 49ers have the talent and experience to make this a tight contest. Given the stakes, this game is expected to be a thrilling affair with playoff implications hanging in the balance.<\/p>\n<p data-start=\"3520\" data-end=\"3764\" data-is-last-node=\"\" data-is-only-node=\"\">For this matchup, the Seahawks may just edge out the 49ers, but it will come down to key plays in the fourth quarter. Whether you\u2019re placing a bet or just enjoying the action, this promises to be a memorable contest in the NFC Divisional Round.<\/p>\n<p data-start=\"3520\" data-end=\"3764\" data-is-last-node=\"\" data-is-only-node=\"\"><img decoding=\"async\" src=\"https:\/\/s.yimg.com\/ny\/api\/res\/1.2\/woaENOU8af9gLBfLmBkdAg--\/YXBwaWQ9aGlnaGxhbmRlcjt3PTY0MDtoPTQyNztjZj13ZWJw\/https:\/\/media.zenfs.com\/en\/sb_nation_articles_115\/30c6266b19b521cd72e79d414f7573d2\" alt=\"NFL Divisional Round odds: Seahawks open as clear favorites over 49ers -  Yahoo Sports\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NFL Divisional Round Preview: San Francisco 49ers vs. Seattle Seahawks The highly anticipated NFL Divisional Round is finally here, and it brings with it an exciting matchup&#8230; <\/p>\n","protected":false},"author":6,"featured_media":139790,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-139789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\ud83d\udd25 GAME CHANGER: 49ers vs. Seahawks NFC Divisional Round \u2014 Seattle favored, but can San Francisco defy the odds in a must\u2011win game at Lumen Field? 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