The Kansas City Chiefs are likely to be without a former first-round pick for the entire 2025 regular season.

Per Ari Meirov of the 33rd Team, Chiefs head coach Andy Reid confirmed that defensive end Felix Anudike-Uzomah suffered a hamstring injury during training camp and is likely going to head to injured reserve, ending the pass rusher’s season.

“Chiefs DE Felix Anudike-Uzomah, their 2023 first-round pick, is likely to be placed on IR with a hamstring injury, per HC Andy Reid,” Meirov posted on X. “That would mean his 2025 season is over.”

#Chiefs DE Felix Anudike-Uzomah, their 2023 first-round pick, is likely to be placed on IR with a hamstring injury, per HC Andy Reid. That would mean his 2025 season is over. pic.twitter.com/ztGkvN3twa

— Ari Meirov (@MySportsUpdate) August 18, 2025

The Kansas City Chiefs are set to lose a DE for the season

Players put on IR during training camp will miss the regular season unless a team chooses to designate them for return before the roster cutdown from 90 to 53 players.

The injury is a setback for the 2023 first-round pick. Anundike-Uzomah has appeared in 34 games and started three in his first two seasons in the league. He’s recorded 41 tackles, two forced fumbles, and three sacks.

If Anundike-Uzomah is placed on IR, the former Kansas State standout will face a pressure season in 2026 to make a case for a contract extension with the Chiefs. In his third season in the league, Anundike was behind Mike Danna on the depth chart, a disappointment for being a Day 1 pick.

With Anundike-Uzomah out, the Chiefs will need rookie Ashton Gillotte to step up in the regular season. The third-round pick has one tackle in the preseason thus far.

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