TOKYO — Murmurs rippled through the packed Tokyo Dome when the velocity flashed onto the scoreboard.

Los Angeles Dodgers phenom Roki Sasaki hit 101 mph on his first pitch in the first inning Wednesday to Chicago Cubs designated hitter Seiya Suzuki in a matchup between the Japanese stars. Every time Sasaki hit triple digits in his major-league debut — five times in his three-inning start — the 42,367 fans comprised largely of Dodgers supporters reacted with a sense of awe.

Cubs fans again didn’t have much to cheer for in a 6-3 loss, getting swept in the Tokyo Series. The Dodgers took a two-run lead in the second and were in command the rest of the game. Each time the Cubs scored, putting up a run in the third through fifth innings, the Dodgers immediately responded in the top half of the frame.

Shohei Ohtani’s solo home run to right-center field generated the loudest pop in the stadium during the series. A replay review, which showed potential fan interference, upheld the call.

Left-hander Justin Steele surrendered five hits and five runs in four innings, hurt by home runs from Tommy Edman (a two-out solo homer in the third) and Enrique Hernández (two-run homer in the fourth).

The Cubs had a chance for a big inning against Sasaki in the third when the right-hander lost command.

Sasaki walked three consecutive hitters following Jon Berti’s one-out single. Although they cut the Dodgers’ lead to 3-1, Sasaki struck out Michael Busch looking and got Matt Shaw to whiff at a slider near the dirt to end the Cubs’ threat.

The Cubs went 1-for-6 with runners in scoring position and left nine on base.