49ers Agree to Sign Former Third-Round Safety to Strengthen Secondary

Santa Clara, CA. The San Francisco 49ers continue reinforcing their defensive unit this offseason, agreeing to sign a young safety known for his ability to generate turnovers and disrupt opposing passing attacks.

The newest addition to the secondary is Andre Cisco, who originally entered the NFL as a third-round pick (No. 65 overall) in the 2021 NFL Draft by the Jacksonville Jaguars.

Since then, he has developed into an instinctive defensive back with strong ball skills.

Across his career so far, Cisco has recorded 270 tackles, eight interceptions, and three forced fumbles, demonstrating a consistent ability to locate the football and create momentum-changing plays.

49ers Agree to Sign Former Third-Round Safety Andre Cisco, per Source pic.twitter.com/qXA5pkRxgS

— NFL Report (@ChiefsFaithful) March 5, 2026

His instincts in reading quarterbacks and reacting to developing routes have made him particularly effective in deep coverage, while his physicality allows him to contribute in run support when needed.

For San Francisco, the move aligns with the organization’s long-standing defensive philosophy. The 49ers have built their identity around pressuring quarterbacks up front while relying on playmakers in the secondary to capitalize on mistakes.

Adding Cisco provides another defensive weapon capable of turning pressure into turnovers, something that has long defined successful 49ers defenses.

At 25 years old, Cisco also offers long-term upside. If he adapts quickly to the system in San Francisco, he could become an important piece in a secondary designed to complement one of the league’s most aggressive defensive fronts.