GOOD NEWS: Rookie Isaac Guerendo gearing up for first start after injuries to 49ers running backs

How 49ers RB Isaac Guerendo Has Prepared Himself to Start

An injury-riddled season got even worse after Week 13 when the San Francisco 49ers learned they’d lost not one, but two running backs.

Christian McCaffrey is out for the regular season due to a PCL injury, ending an abbreviated campaign that never got a chance to gain steam. His backup, Jordan Mason, is also likely out for the season after landing on injured reserve due to an ankle injury with just five weeks left.

Next in line: rookie Isaac Guerendo, a Louisville product who has seen just 42 carries this season. He’s averaged 5.9 yards per rush, gaining 246 yards and scoring two touchdowns — including one in San Francisco’s most recent loss — but he’s still very green for a new starter.

San Francisco (5-7) doesn’t have much of a choice, though. With this in mind, coach Kyle Shanahan backed his new starting runner when speaking with reporters Wednesday.

“I think he is ready to go,” Shanahan said, via the team’s official site. “(He) did some decent things when he started out. He didn’t get a lot of carries, had some ups and downs but got better through everything. Then, when he got the bulk of the carries, I want to say some more versus Seattle, he only got better and he’s gotten better throughout the year. So, I think he’s ready for this.”

In the game Shanahan referenced, Guerendo saw 10 carries, gaining 99 yards in a 36-24 win in Seattle in a game played in front of a national audience. Since then, he’s received 20 carries, gaining 106 yards and scoring two touchdowns.

That’s pretty solid production, but Guerendo hasn’t yet seen a full workload in a Shanahan offense — a scheme, by the way, that’s known for taking unheralded runners and turning them into legitimate producers. He’ll see plenty more Sunday in a home game against the 4-8 Bears.

“That’s one of those things that just comes with reps. The more reps you get, the more you get the feel for it,” Guerendo said. “The more (reps) I’ve gotten, I think I’ve caught onto that. That’s something that has helped me and will continue to help me.”

Guerendo will make his first start with a full week of work under his belt, which is more than he could say about any prior week in his nascent NFL career. We’ll see if he’s ready for the moment.

Related Posts

🚨 SAINTS RISE TO NFL SHOCK, TYLER SHOUGH EMERGES AS FRANCHISE QB AFTER 2025 DRAFT REDRAFT 🚨 Tyler Shough’s explosive climb in the 2025 draft redraft has made him New Orleans’ new potential franchise QB. Big things ahead for the Saints?

The perception around New Orleans Saints quarterback Tyler Shough has completely shifted. New Orleans fans saw what Shough can do in the second half of the 2025 season…

🚨 BREAKING: GREEN BAY PACKERS ANNOUNCE $1.2 BILLION LAMBEAU FIELD RENOVATION PLAN 🚨 The Pаckerѕ аre mаkіng а gаme-chаngіng move wіth а $1.2 bіllіon renovаtіon to Lаmbeаu Fіeld. Thіѕ monumentаl іnveѕtment wіll enhаnce the fаn exрerіence аnd рreѕerve the іconіc “Frozen Tundrа” for decаdeѕ to come!

The Green Bаy раckerѕ аre іmаgіned to hаve juѕt ѕtunned the entіre NFL unіverѕe wіth а jаw-droрріng аnnouncement — а reрorted $1.2 BіLLіON renovаtіon рlаn for the…

🔥 PACKERS FAN!! BIG NEWS: League buzz around Malik Willis is heating up fast. With reports that nine NFL teams have reached out to the Packers about a trade, Willis is suddenly being viewed as more than just depth. The question now is whether Green Bay holds onto him — or cashes in while the interest is real.

NFL Trade Rumors Ignite as Nine Teams Contact Packers About Malik Willis The NFL rumor mill exploded almost overnight. According to multiple league sources, nine teams have…

🚨EXCLUSIVE: Dallas Cowboys Cheerleaders bring live tour experience to Tulsa! The iconic squad is hitting the road, giving fans a chance to see their electrifying performances up close. What can Tulsa expect from this unforgettable tour stop, and how will the Cowboys’ cheerleaders captivate the crowd? 👇👇👇

Dallas Cowboys Cheerleaders LIVE! Tour Comes to Tulsa for an Exclusive Behind-the-Scenes Experience The Dallas Cowboys Cheerleaders, one of the most iconic cheerleading squads in the world,…

Steelers Closing In on Blockbuster Vikings Assistant Hire as Next Offensive Coordinator – Massive Shake-Up Brewing Under McCarthy

After news broke on Tuesday that several Saints assistants had chosen to stay in New Orleans rather than take the offensive coordinator job in Pittsburgh, it seems…

Cam Heyward’s Glowing Praise for Mike McCarthy: “Offense Is About to Explode” – Clear Sign Steelers’ Own Captain Is Embracing the Post-Tomlin Era After Loyal Years Under Mike

Under offensive-minded head coach Mike McCarthy, Cam Heyward expects the Pittsburgh Steelers’ offense to substantially grow in 2026. No matter what the offense looks like or how…