The San Francisco 49ers suffered their biggest loss of the season in Week 12 on the road against the Green Bay Packers. The 38-10 setback marked the 49ers’ biggest margin of defeat since Week 9 of the 2018 season, a 39-10 loss to the Los Angeles Rams.

San Francisco had a season-low 241 yards of offense against the Packers and committed three turnovers for the third time this season. They were operating without Brock Purdy at quarterback for the first time in two years as Brandon Allen started in his place.

Purdy missed his first NFL game due to injury because of a shoulder issue that developed during the 49ers’ Week 11 loss to the Seahawks.

This week, the 49ers take on one of the top teams in the NFL in prime time. The Buffalo Bills, winners of their last six games and fresh off a bye week, will host the 49ers on “Sunday Night Football.”

Here’s the latest on whether Purdy will suit up in the freezing temperatures.

Will Brock Purdy play this week?

Purdy is listed as questionable this week with a shoulder injury. He was limited in practice Wednesday in a similar fashion to a week ago and he ended up missing last Sunday’s game.

Purdy did some “light throwing” on Monday, per coach Kyle Shanahan, and rested on Tuesday. He threw on Monday without any reported shoulder issue.

Week 12 marked the first time Purdy missed a start with injury since he took over in Week 14 of the 2022 NFL season. His most recent significant injury came in the NFC championship game in January 2023, when he tore the UCL in his throwing arm and left the game after throwing four passes.

Allen had a tough game against the Packers in his first start since Week 18 of the 2021 NFL season. He completed 17 of 29 passes for 199 yards, one touchdown, and one interception. He had two carries for 5 yards and two fumbles (one lost) as well.

Brock Purdy injury

Purdy took a hard hit to his shoulder area at some point during the 49ers’ loss to the Seattle Seahawks. He finished that day 21-for-28 passing but averaged a season-low 5.7 yards per attempt. Shanahan denied limiting downfield passing in the game due to an injury, saying instead that Seattle’s coverages changed the game plan.

Brock Purdy stats

In 10 games this season, Purdy has completed 202 of 306 passes for 2,613 yards, 13 touchdowns, and eight interceptions with a 95.9 passer rating. He’s also rushed 51 times for 267 yards and four touchdowns.

49ers QB depth chart

With Purdy’s status up in the air, Allen may be the starter in Buffalo again. Here’s how the depth chart looks if Purdy can’t go:

• Brandon Allen
• Joshua Dobbs

The 49ers also have quarterback Tanner Mordecai signed to the practice squad.

This article originally appeared on USA TODAY: Brock Purdy injury update: Latest on 49ers QB’s status for Week 13