December football in Indianapolis always feels intense—chilly winds, high stakes, and every play loaded with cross-conference implications. In Week 16, 49ers vs. Colts takes the Monday night stage, the kind of matchup where one big play can reshape playoff pictures for the final stretch.
TIME, DATE, LOCATION
Matchup: San Francisco 49ers at Indianapolis Colts (Week 16)
Date: Monday, December 22, 2025
Kickoff: 8:15 PM ET / 7:15 PM CT / 5:15 PM PT
Venue:
Lucas Oil Stadium — Indianapolis, Indiana
TV & STREAMING
TV: ABC / ESPN (prime-time window)
Streaming: ESPN.com + ESPN App (with a participating TV provider)
RADIO
Colts Radio (flagship): 93.5 & 107.5 The Fan
49ers Radio (flagship): KNBR 680 AM / KSAN 107.7 FM
GAME PREVIEW
This one’s about execution and seizing opportunities. Lucas Oil Stadium at night favors the team that controls the line of scrimmage, avoids self-inflicted errors, and capitalizes when the game tightens up in the second half. Interconference games demand who handles the pressure better. With the 49ers at 10–4 battling for positioning in the NFC West, while the 8–6 Colts look to strengthen their hold in the AFC South playoff race, it’s a clash of contenders vying for postseason momentum.
The blueprint is simple:
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Win the turnover battle
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Avoid drive-killing penalties
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Finish in the red zone
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Limit explosive plays and tackle clean
3 MATCHUPS THAT COULD DECIDE IT
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PASS PROTECTION VS. PRESSURE:
Whoever keeps their QB upright dictates the tempo. -
HIDDEN YARDS:
Field position, punts, and return lanes can decide a one-score game. -
RED-ZONE EXECUTION:
Field goals keep it close—touchdowns swing the night.
CLOSING THOUGHT
49ers at Colts in Week 16 isn’t about flash—it’s about grinding out a win in the cold, handling the prime-time lights, and owning the moment. If Indianapolis starts aggressive and forces mistakes, Lucas Oil Stadium turns electric. If San Francisco imposes their will early, the playoff path clears.
