Colts vs. 49ers at Lucas Oil Stadium — Kickoff Time and Full Game Details

The Indianapolis Colts will host the San Francisco 49ers in Week 16 of the 2025 NFL regular season on Monday, December 22, 2025, at Lucas Oil Stadium in Indianapolis, Indiana. This game is officially scheduled to kickoff at 8:15 p.m. Eastern Standard Time (EST), with gates opening earlier in the evening and gameday activities starting well before kickoff. Lucas Oil Stadium+1

Kickoff Time and Venue

• Date: Monday, December 22, 2025

• Kickoff: 8:15 p.m. EST

• Venue: Lucas Oil Stadium, Indianapolis, Indiana

• Home Team: Indianapolis Colts

• Visiting Team: San Francisco 49ers Lucas Oil Stadium+1

Lucas Oil Stadium is the full-time home of the Indianapolis Colts and features a fixed dome roof, ensuring that weather conditions do not directly impact play on the field. The stadium has a seating capacity of approximately 63,000 for NFL games and provides a controlled environment for fans and players alike. Wikipédia

Pre-Game Schedule
According to the official event details published by the Colts and Lucas Oil Stadium, the timeline for the evening is as follows:

• Ticket Office Opens: 4:15 p.m. EST

• Touchdown Town Fan Experience Opens: 5:00 p.m. EST

• Stadium Gates Open: 6:15 p.m. EST

• Kickoff: 8:15 p.m. EST Lucas Oil Stadium

Broadcast and Streaming
This Week 16 matchup will be nationally televised and available across multiple platforms. The game is scheduled to air on ESPN, ABC, ESPN Deportes, and will also be available for streaming on Disney+, marking a notable distribution milestone. ESPN Press Room U.S.

Weather Context and Local Conditions
Although Lucas Oil Stadium is a domed venue, external weather can impact travel to and from the game. Historical and extended forecasts for Indianapolis in late December indicate typical cold winter conditions with daytime temperatures often near or below freezing, and nighttime temperatures well below freezing. Average December highs in Indianapolis range near the mid-to-low 30s Fahrenheit (around 0–4°C), and lows can fall into the 20s°F (around –3 to –5°C) on average. Weather Spark+1

Because the game is indoors, internal stadium temperatures will be comfortable and climate controlled for both players and fans, mitigating the impact of winter weather on the competition itself. Reddit

Team Standings and Stakes
Coming into this Week 16 matchup, the 49ers and Colts are positioned in the playoff chase within their respective conferences:

• San Francisco holds a strong record and standing within the NFC,

• Indianapolis remains competitive in the AFC South division. Odds Shark

Game Notes and Logistics
Fans attending the game should plan for potential traffic and weather delays typical of mid-winter travel in the Midwest. Gameday parking, public transportation details, and entrance policies are available through the Colts’ official gameday guides.