How to watch Carolina Panthers vs. San Francisco 49ers
- Venue: Levi’s Stadium
- Time: 8:15 p.m. ET
- Streaming: Fubo (Stream now)
- TV: ESPN
- Watching in person? Get tickets on StubHub.
Carolina vs. San Francisco odds
- Spread: San Francisco -7 (-110), Carolina +7 (-110)
- Favorite Moneyline: San Francisco -350
- Underdog Moneyline: Carolina +275
- Total: 49
- Total Over Odds: -110
- Total Under Odds: -110
Injury reports
49ers
No injuries listed
Panthers
No injuries listed
Stats to know
- The 49ers have put roughly the same amount of points on the board per game this season (23.7) as the Panthers have allowed (22.6).
- Carolina’s defense has allowed an average of 325.9 yards per game this season, 23.5 yards fewer than the 349.4-yard average from San Francisco’s offense. SF picks up 5.7 yards per play and the Carolina allows 5.8.
- The 49ers have allowed an average of 22.9 points per game, 4.1 more than the 18.8 the Panthers have scored.
- San Francisco’s defense has surrendered 352.9 yards per game in 2025, 38.6 yards more than the 314.3 Carolina’s offense has averaged. Carolina gains 5.3 yards per play and San Francisco allows 5.8.
