Get ready, football fans — the desert is about to ignite! The Arizona Cardinals are set to host the powerhouse San Francisco 49ers at State Farm Stadium on Sunday, November 16, 2025, with kickoff officially confirmed for 2:05 PM MST (4:05 PM ET). This isn’t just another divisional showdown — it’s a fiery NFC West rivalry where pride, power, and playoff dreams collide under the Arizona sun.

🏈 Game Day Details

• Matchup: San Francisco 49ers vs. Arizona Cardinals

• Date: Sunday, November 16, 2025

• Kickoff: 2:05 PM MST / 4:05 PM ET

• Venue: State Farm Stadium, Glendale, Arizona

• Broadcast: FOX (National Game)

• Expected Attendance: Over 65,000 fans ready to shake the desert

🎙 “Every time the Niners roll into the desert, the energy hits different,” said former wideout Larry Fitzgerald. “This game always brings out the best — and the loudest — in Arizona.”

☀️ Weather Forecast: The Desert Is Ready for Football

Mother Nature is delivering a perfect football afternoon in Glendale. Expect sunny skies, light winds, and dry desert air, the kind of weather every coach dreams about when drawing up plays.

Game Day Forecast:

• Temperature: 73°F (23°C) at kickoff

• Conditions: Clear and sunny

• Wind: Gentle 5–7 mph breeze

• Chance of Rain: 0%

• Humidity: Around 18%

With State Farm Stadium’s retractable roof, conditions will be flawless whether it’s open to the sky or closed to amplify crowd noise. This is pure football weather — crisp, bright, and made for highlight plays.

🌤 “Arizona’s weather is the great equalizer — no excuses, just football,” said FOX meteorologist Sarah Walsh.

🔥 Rivalry in the Desert: Redemption vs. Revenge

The 49ers enter as the NFC’s juggernaut — disciplined, balanced, and built to dominate. Brock Purdy continues to run Kyle Shanahan’s system with robotic precision, while Christian McCaffrey and Deebo Samuel turn every touch into a potential touchdown.

But the Cardinals? They’re done being overlooked. With Kyler Murray healthy and firing on all cylinders, and rookie phenom Marvin Harrison Jr. already looking like a superstar, Arizona is ready to turn the tables. This isn’t just about a win — it’s about respect.

💬 “We’re not scared of the 49ers,” said Kyler Murray after practice. “We respect them, but this is our house. The desert belongs to us.”

🧠 Key Matchups to Watch

1. Christian McCaffrey vs. Zaven Collins & Co. – Can Arizona’s young defense contain the NFL’s most dynamic playmaker?

2. Kyler Murray vs. Nick Bosa – A test of agility versus power; if Murray escapes Bosa’s grasp, Arizona could turn broken plays into big ones.

3. Deebo Samuel vs. Marco Wilson – A physical duel that could decide the passing game’s tempo.

4. Coaching Chess Match: Kyle Shanahan’s offensive wizardry faces Jonathan Gannon’s aggressive defensive schemes. Expect mind games all afternoon.

🗣 “This game is about precision and guts,” said NFL analyst Rich Eisen. “The first mistake could decide everything.”

🏟️ Inside State Farm Stadium: The Roar of the Desert

State Farm Stadium isn’t just a venue — it’s a cathedral of noise when the Cardinals play at home. The sound bounces off the closed roof, creating a thunderous echo that shakes through every player’s helmet.

🔊 “When 65,000 fans start chanting ‘Red Sea,’ it’s goosebumps,” said linebacker Dennis Gardeck. “That sound carries us — especially against the Niners.”

The 49ers know it’s hostile territory. But for a team forged in big moments, they welcome the noise. It’s what they live for.

⚡ Momentum and Motivation

The 49ers come into this matchup chasing another Super Bowl run, but they can’t afford to overlook an improving Cardinals squad. Arizona’s offense has started clicking, their defense is tackling with confidence, and the home crowd will make every snap a battle.

Meanwhile, San Francisco’s goal is simple — stay sharp, stay dominant, and leave no doubt.

💪 “It’s not about who talks more,” said Nick Bosa. “It’s about who hits harder and who lasts longer.”

🔮 Expert Predictions

• ESPN: 49ers 31 – Cardinals 20
  San Francisco’s experience and versatility overwhelm the young Arizona team.

• NFL Network: Cardinals 27 – 49ers 26
  A bold upset call — Murray finds Harrison Jr. in the end zone for a late-game shocker.

• FOX Sports: 49ers 28 – Cardinals 24
  A thriller to the end, with McCaffrey sealing it in the fourth quarter.

🏆 “Don’t underestimate the Cardinals at home,” warned Michael Strahan. “The desert heat does strange things to favorites.”

💬 What’s at Stake

For the 49ers, it’s about staying atop the NFC and sending a message that no one can slow their march to the playoffs. For the Cardinals, it’s about proving they belong in the conversation again — that this rebuild isn’t about patience, but power.

Win or lose, this game will define the tone for both teams heading into the final stretch of the season.

🏁 Final Word

When the clock hits 2:05 PM MST, the desert becomes a battleground.
The Cardinals have the heart. The 49ers have the muscle.
But only one team will walk out with the statement win they need.