The 49ers head into this week riding momentum, matching the Buccaneers with identical 4–1 records.
San Francisco has strung together four wins out of five, including a strong road performance in Week 5. Led by the versatile
Christian McCaffrey and with solid contributions from their passing game, the 49ers boast one of the more balanced offenses in the NFL this season. Their defense, even in the absence of Nick Bosa, has held firm under pressure, with linebackers Fred Warner and Dre Greenlaw providing consistency up the middle.
On the other side, Tampa Bay is also 4–1 after a thrilling Week 5 victory over Seattle, paced by Baker Mayfield
’s efficient play and a defense that has forced timely turnovers. The Buccaneers remain dangerous at home in Raymond James Stadium, especially when the game gets tight down the stretch.
This matchup pits two teams with matching records and high expectations — it’s a key test of depth, coaching, and execution.
Here is everything you need to know about the 49ers this week, including TV and streaming options for the Week 6 NFL game.
What channel is the 49ers game on today?
Local TV channels: KPIX channel 5 (San Francisco), WTSP channel 10 (Tampa)
Out-of-market TV channel:Â CBS
Live stream:
Paramount+, Fubo
The 49ers game airs on CBS. Bay Area fans can watch on KPIX 5, while those in Tampa can tune to WTSP 10. Jim Nantz
 and Tony Romo have the call for CBS’s late window.
49ers game start time
Date:Â Sunday, Oct. 12
Time:Â 4:25 p.m. ET
Kickoff is 4:25 p.m. ET at Raymond James Stadium
 in Tampa, Florida. ESPN.com+1
49ers radio station
Radio: SiriusXM channel 382 (49ers broadcast), channel 226 (Buccaneers broadcast)
You can listen live on SiriusXM with the team feeds listed above.
49ers 2025 schedule
| Week | Date | Matchup | Time (ET) | TV/Result |
|---|---|---|---|---|
| 1 | Sept. 7 | @ Seahawks | — | 49ers 17, Seahawks 13 |
| 2 | Sept. 14 | @ Saints | — | 49ers 26, Saints 21 |
| 3 | Sept. 21 | vs. Cardinals | — | 49ers 16, Cardinals 15 |
| 4 | Sept. 28 | vs. Jaguars | — | Jaguars 26, 49ers 21 |
| 5 | Oct. 2 | @ Rams | — | 49ers 26, Rams 23 (OT) |
| 6 | Oct. 12 | @ Buccaneers | 4:25 p.m. | CBS, Fubo, Paramount+ |
| 7 | Oct. 19 | vs. Falcons | 8:20 p.m. | NBC, Fubo, Peacock |
| 8 | Oct. 26 | @ Texans | 1:00 p.m. | FOX |
| 9 | Nov. 2 | @ Jets | 1:00 p.m. | CBS |
| 10 | Nov. 9 | vs. Rams | 4:25 p.m. | FOX |
| 11 | Nov. 16 | @ Cardinals | 4:05 p.m. | FOX |
| 12 | Nov. 24 (Mon) | vs. Panthers | 8:15 p.m. | — |
| 13 | Nov. 30 | @ Browns | 1:00 p.m. | CBS |
| 14 | — | BYE | — | — |
| 15 | Dec. 14 | vs. Titans | 4:25 p.m. | FOX |
| 16 | Dec. 22 (Mon) | @ Colts | 8:15 p.m. | — |
| 17 | Dec. 28 | vs. Bears | 8:20 p.m. | NBC |
| 18 | TBD | vs. Seahawks | TBD | TBD |
Results and listings per ESPN schedule; Week 6 opponent/time per league listings. ESPN.com
NFL Week 6 schedule
Thursday, Oct. 9, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| Philadelphia at New York (Giants) | 8:15 p.m. | Prime Video |
Sunday, Oct. 12, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| Denver vs. New York (Jets) — London | 9:30 a.m. | NFL Net / NFL+ |
| Dallas at Carolina | 1 p.m. | FOX |
| Los Angeles (Rams) at Baltimore | 1 p.m. | FOX |
| Arizona at Indianapolis | 1 p.m. | FOX |
| Seattle at Jacksonville | 1 p.m. | FOX |
| New England at New Orleans | 1 p.m. | CBS |
| Cleveland at Pittsburgh | 1 p.m. | CBS |
| San Francisco at Tampa Bay | 4:25 p.m. | CBS, Paramount+ |
| Tennessee at Las Vegas | 4:05 p.m. | FOX |
| Cincinnati at Green Bay | 4:25 p.m. | CBS |
| Detroit at Kansas City | 8:20 p.m. | NBC, Peacock |
Monday, Oct. 13, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| Buffalo at Atlanta | 7:15 p.m. | ABC/ESPN |
(Times/TV per NFL, ESPN, and FOX Sports listings.)Â The Big Lead+3operations.nfl.com+3ESPN.com+3
Viewers can also stream the game on Paramount+ or Fubo. foxsports.com
